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In this chapter, we describe advances in our understanding of GIRK channel fugirknction based on recent high-resolution atomic structures of inwardly rectifying K (+) channels discussed in the context of classical structure-function experiments.

G protein-coupled inwardly rectifying potassium (GIRK) channels can be activated or inhibited by different classes of receptors, suggesting a role for G proteins in determining signaling specificity.

Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come together to form GIRK ion channels.

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